Castro Dias M, Coisne C, Baden P, Enzmann G, Garrett L, Becker L, Hölter SM; German Mouse Clinic Consortium, Hrabě de Angelis M, Deutsch U, Engelhardt B. Claudin-12 is not required for blood-brain barrier tight junction function.Fluids Barriers CNS. 2019 Sep 12;16(1):30. doi: 10.1186/s12987-019-0150-9.

Castro Dias M, Mapunda JA, Vladymyrov M, Engelhardt B. Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. Int J Mol Sci. 2019 Oct 29;20(21). pii: E5372. doi: 10.3390/ijms20215372. Review.

Castro Dias M, Coisne C, Lazarevic I, Baden P, Hata M, Iwamoto N, Francisco DMF, Vanlandewijck M, He L, Baier FA, Stroka D, Bruggmann R, Lyck R, Enzmann G, Deutsch U, Betsholtz C, Furuse M, Tsukita S, Engelhardt B (2019) Claudin-3-deficient C57BL/6J mice display intact brain barriers. Sci Rep. 9(1):203.


Gelderblom M, Gallizioli M, Ludewig P, Thom V, Arunachalam P, Rissiek B, Bernreuther C, Glatzel M, Korn T, Arumugam TV, Sedlacik J, Gerloff C, Tolosa E, Planas AM, Magnus T (2017) IL-23 producing conventional dendritic cells control the detrimental IL-17 response in stroke. J Stroke (accepted)

Kierdorf K, Prinz M. (2017) Microglia in steady state. J Clin Invest. 127(9):3201-3209. Review.

Erny D, Hrabě de Angelis AL, Prinz M. (2017) Communicating systems in the body: how microbiota and microglia cooperate. Immunology. 150(1):7-15. Review.

Porrini V, Sarnico I, Benarese M, Branca C, Mota M, Lanzillotta A, Bellucci A, Parrella E, Faggi L, Spano P, Imbimbo BP, Pizzi M (2017) Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation. Int J Mol Sci 18;18(1)

Porrini V*, Mota M*, Parrella E, Bellucci A, Benarese M, Faggi L, Tonin P, Spano PF, Pizzi M (2017) Mild Inflammatory Profile without Gliosis in the c-Rel Deficient Mouse Modeling a Late-Onset Parkinsonism. Front Aging Neurosci 19;9:229 (*These authors have contributed equally to this work)

Engelhardt B, Vajkoczy P, Weller RO (2017) The movers and shapers in immune privilege of the CNS. Nat Immunol. 18(2):123-131. Review.

Bridel C, Koel-Simmelink MJA, Peferoen L, Derada Troletti C, Durieux S, Gorter R, Nutma E, Gami P, Iacobeus E, Brundin L, Kuhle J, Vrenken H, Killestein J, Piersma SR, Pham TV, De Vries HE, Amor S, Jimenez CR, Teunissen CE (2017) Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro. Neuropathol Appl Neurobiol. Epub ahead of print.


Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn B, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente D, Docagne F (2016) Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis. Brain 139:2406-2419.                        

Goldmann T, Wieghofer P, Jordão MJ, Prutek F, Hagemeyer N, Frenzel K, Amann L, Staszewski O, Kierdorf K, Krueger M, Locatelli G, Hochgerner H, Zeiser R, Epelman S, Geissmann F, Priller J, Rossi FM, Bechmann I, Kerschensteiner M, Linnarsson S, Jung S, Prinz M  (2016) Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat Immunol 17:797-805.

Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M (2016) Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J. 16:1730-44

Tietz SM, Zwahlen M, Haghayegh Jahromi N, Baden P, Lazarevic I, Enzmann G, Engelhardt B (2016) Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences. Eur J Immunol 46:2481-2483.

Kaminska B, Mota M, Pizzi M (2016) Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation. Biochim Biophys Acta 1862:339-351.

Ludewig P, Gallizioli M, Urra X, Behr S, Brait VH, Gelderblom M, Magnus T, Planas A (2016) Dendritic cells in brain diseases. Biochim Biophys Acta 1862:352-367.

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. (2016) Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. Glia. 64:1492-507.

Parrella E, Porrini V, Iorio R, Benarese M, Lanzillotta A, Mota M, Fusco M, Tonin P, Spano P, Pizzi M  (2016) PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia. Brain Res 1648:409-417.

Khan MA*, Schultz S*, Othman A, Fleming T, Lebrón-Galán R, Rades D, Clemente D, Nawroth PP, Schwaninger M  (2016) Hyperglycemia in stroke impairs polarization of monocytes/macrophages to a protective noninflammatory cell type. J Neurosci 36:9313-9325. *these authors contributed equally to this work

Borjini N, Fernández M, Giardino L, Calzà L (2016) Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. J Neuroinflammation. 13(1):291.

Miró-Mur F, Urra X, Gallizioli M, Chamorro A, Planas AM. (2016) Antigen Presentation After Stroke. Neurotherapeutics. 13(4):719-728. Review.

Assmann JC, Körbelin J, Schwaninger M (2016) Genetic manipulation of brain endothelial cells in vivo. Biochim Biophys Acta 1862:381-394.

Derada Troletti C, de Goede P, Kamermans A, de Vries HE (2016) Molecular alterations of the blood–brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition. Biochim Biophys Acta 1862:452-460.

Gliem M, Schwaninger M, Jander S (2016) Protective features of peripheral monocytes/macrophages in stroke. Biochim Biophys Acta 1862:329-338.

Kanninen KM, Bister N, Koistinaho J, Malm T (2016) Exosomes as new diagnostic tools in CNS diseases. Biochim Biophys Acta 1862:403-410.

Lopes Pinheiro MA, Kooij G, Mizee MR, Kamermans A, Enzmann G, Lyck R, Schwaninger M, Engelhardt B, de Vries HE (2016) Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochim Biophys Acta 1862:461-471.

Mehra A, Ali C, Parcq J, Vivien D, Docagne F (2016) The plasminogen activation system in neuroinflammation. Biochim Biophys Acta 1862:395-402.

Melero-Jerez C, Ortega MC, Clemente D (2016) Myeloid derived suppressor cells in inflammatory conditions of the central nervous system. Biochim Biophys Acta 1862:368-380.

Wieghofer P, Prinz M (2016) Genetic manipulation of microglia during brain development and disease. Biochim Biophys Acta 1862:299-309.


Lanzillotta A, Porrini V, Bellucci A, Benarese M, Branca C, Parrella E, Spano PF, Pizzi M (2015) NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases. Front Neurol. 6:98. Review.

Rolova T, Dhungana H, Korhonen P, Valonen P, Kolosowska N, Konttinen H, Kanninen K, Tanila H, Malm T, Koistinaho J. (2015) Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage. Aging Dis. 7(4): 450–465.

Tietz S, Engelhardt B (2015) Brain barriers: Crosstalk between complex tight junctions and adherens junctions. J Cell Biol. 209(4):493-506. Review.

Jordão MJ, Prinz M (2015) Nr4a1 discloses the sympathetic side of monocytes. Nat Immunol 16:1211-1213.

Kamphuis WW, Derada Troletti C, Reijerkerk A, Romero IA, de Vries HE (2015) The blood-brain barrier in multiple sclerosis: microRNAs as key regulatorsm. CNS Neurol Disord Drug Targets 14:157-167.


Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N, Schwaninger M (2014) Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest 124:2188-92.